Integrative Leakage Correction for Contrast Agent Extravasation in Dynamic Susceptibility Contrast (DSC) - MRI
Patent Number: US20180249925A1
Executive Summary:
General Description:
Contrast agent leakage is a common occurrence during perfusion MRI scans. This methodology improves techniques to measure that leakage. Without needing a second MRI or an additional injection, this model makes simultaneous calculations to obtain accurate measurements of relative cerebral volume and other parameters.
Scientific Progress:
A standalone prototype exists for Mac, as does prototype source code in Matlab. External institutions and companies are evaluating the prototype.
Future Directions:
Strengths:
Weaknesses:
Patent Status:
Legal status: Pending
Publication PMID: 28034995, 27079371, 26971534
Publications:
Leu, K., Boxerman, J.L., and Ellingson, B.M. Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas. AJNR Am J Neuroradiol. 2017 Mar;38(3):478-484.
Leu, K., Boxerman, J.L., Cloughesy, T.F., Lai, A., Nghiemphu, P.L., Liau, L.M., Pope, W.B., and Ellingson, B.M. Improved leakage correction for single-echo dynamic susceptibility contrast perfusion MRI estimates of relative cerebral blood volume in high-grade gliomas by accounting for bidirectional contrast agent exchange. AJNR Am J Neuroradiol. 2016 Aug;37(8):1440-6.
Leu, K., Boxerman, J.L., Lai, A., Nghiemphu, P.L., Pope, W.B., Cloughesy, T.F., and Ellingson, B.M. Bidirectional Contrast agent leakage correction of dynamic susceptibility contrast (DSC)-MRI improves cerebral blood volume estimation and survival prediction in recurrent glioblastoma treated with bevacizumab. J Magn Reson Imaging. 2016 Nov;44(5):1229-1237.
Inventor Bio: Benjamin Ellingson
http://www.bri.ucla.edu/people/benjamin-m-ellingson-ph
Executive Summary:
- Invention Type: Diagnostic
- Patent Status: Pending
- Patent Link: https://patents.google.com/patent/US20180249925A1
- Related Patent Link: https://patents.google.com/patent/WO2017040523A1
- Research Institute: University of California, Los Angeles
- Disease Focus: Gliomas, including Glioblastoma
- Basis of Invention: Correcting for contrast agent leakage during MRI and CT imaging
- How it works: Improving the model for correcting contrast leakage during perfusion MRI scans. Compartmental modeling of contrast agent leakage into and out of surrounding tissue provides more accurate calculations of physiological diagnostic and prognostic parameters
- Lead Challenge Inventor: Benjamin Ellingson
- Inventors: Kevin Leu, Benjamin Ellingson
- Development Stage: Prototype evaluation
- Novelty:
- Can calculate dynamic contrast enhanced MRI parameters with only one injection
- Lowers variability of perfusion parameter estimations
- Clinical Applications:
- Dynamic susceptibility contrast (DSC) perfusion MRI
- Dynamic computed tomography (CT) perfusion imaging
- Brain tumor imaging
- Stroke and ischemic disease
- Traumatic brain injury (TBI)
General Description:
Contrast agent leakage is a common occurrence during perfusion MRI scans. This methodology improves techniques to measure that leakage. Without needing a second MRI or an additional injection, this model makes simultaneous calculations to obtain accurate measurements of relative cerebral volume and other parameters.
Scientific Progress:
A standalone prototype exists for Mac, as does prototype source code in Matlab. External institutions and companies are evaluating the prototype.
Future Directions:
- Clinical validation
Strengths:
- Applicability to gliomas and other neurological disorders
- Properly correcting for contrast agent leakage, unlike currently available models
Weaknesses:
- Prototype has not yet been fully validated (evaluation ongoing)
Patent Status:
Legal status: Pending
- Priority date: 2015-08-30
- Filing date: 2016-08-30
- Publication date: 2018-09-06
Publication PMID: 28034995, 27079371, 26971534
Publications:
Leu, K., Boxerman, J.L., and Ellingson, B.M. Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas. AJNR Am J Neuroradiol. 2017 Mar;38(3):478-484.
Leu, K., Boxerman, J.L., Cloughesy, T.F., Lai, A., Nghiemphu, P.L., Liau, L.M., Pope, W.B., and Ellingson, B.M. Improved leakage correction for single-echo dynamic susceptibility contrast perfusion MRI estimates of relative cerebral blood volume in high-grade gliomas by accounting for bidirectional contrast agent exchange. AJNR Am J Neuroradiol. 2016 Aug;37(8):1440-6.
Leu, K., Boxerman, J.L., Lai, A., Nghiemphu, P.L., Pope, W.B., Cloughesy, T.F., and Ellingson, B.M. Bidirectional Contrast agent leakage correction of dynamic susceptibility contrast (DSC)-MRI improves cerebral blood volume estimation and survival prediction in recurrent glioblastoma treated with bevacizumab. J Magn Reson Imaging. 2016 Nov;44(5):1229-1237.
Inventor Bio: Benjamin Ellingson
http://www.bri.ucla.edu/people/benjamin-m-ellingson-ph
