Wearable Magnetic Drug Targeting Device for Efficient Focusing of Therapy to Brain Tumors
Patent Number: Pending
Executive Summary:
General Description:
The ultimate goal of brain tumor-targeted drug delivery is to target drugs across the blood brain barrier and increase drug accumulation in the tumor, while reducing toxicity in normal brain tissue. A promising drug delivery approach is magnetic drug targeting, which can be realized if a drug delivery vehicle possesses a strong magnetic moment. This invention is a wearable, point of care, treatment device that uses magnets to drive therapeutic agents across the blood brain barrier and into the tumor, where they specifically kill cancer cells and reduce harmful side effects.
Scientific Progress:
The device can effectively trap magnetic nanoparticles injected into circulation in a pre-clinical model and importantly the particles cross the blood brain barrier and enter into the tumor.
Future Directions:
Strengths:
Weaknesses:
Patent Status:
Legal status: Pending
Publication PMID: 26284300, 26391797, 27490757
Publications:
Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF, Farrow N, Dobson J, Conner J, Wild JM, Lewis C. Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting. Nat Commun. 2015 Aug 18;6:8009.
Bain J, Ruiz-Pérez L, Kennerley AJ, Muench SP, Thompson R, Battaglia G, Staniland SS. In situ formation of magnetopolymersomes via electroporation for MRI. Sci Rep. 2015 Sep 22;5:14311.
Bakhshi PK, Bain J, Gul MO, Stride E, Edirisinghe M, Staniland SS. Manufacturing Man-Made Magnetosomes: High-Throughput In Situ Synthesis of Biomimetic Magnetite Loaded Nanovesicles. Macromol Biosci. 2016 Nov;16(11):1555-1561.
Inventor Bio: Munitta Muthana
https://www.sheffield.ac.uk/oncology-metabolism/staff/muthana
Executive Summary:
- Invention Type: Therapeutic and Device
- Patent Status: Pending
- Patent Link: Pending
- Research Institute: University of Sheffield
- Disease Focus: Glioblastoma
- Basis of Invention: A wearable, point of care, treatment device that enables targeted delivery of therapeutics to brain cancer patients
- How it works: The wearable device contains a magnet array, which has the magnetic strength of a MRI scanner, but is miniaturized, thereby allowing it to fit into an apparatus (helmet) tailored to the precise shape of a patient’s head. This will enable a patient to wear the magnetic device while the nanoparticle-based therapeutic agent is infused into circulation
- Lead Challenge Inventor: Munitta Muthana
- Development Stage: Prototype evaluation
- Novelty:
- Wearable device for specific targeting of chemotherapeutic to tumors and reduced side effects
- Contains a miniaturized magnet array with the magnetic strength of a MRI scanner
- Clinical Applications:
- Brain tumor-targeted drug delivery across the blood brain barrier to treat glioblastoma
General Description:
The ultimate goal of brain tumor-targeted drug delivery is to target drugs across the blood brain barrier and increase drug accumulation in the tumor, while reducing toxicity in normal brain tissue. A promising drug delivery approach is magnetic drug targeting, which can be realized if a drug delivery vehicle possesses a strong magnetic moment. This invention is a wearable, point of care, treatment device that uses magnets to drive therapeutic agents across the blood brain barrier and into the tumor, where they specifically kill cancer cells and reduce harmful side effects.
Scientific Progress:
The device can effectively trap magnetic nanoparticles injected into circulation in a pre-clinical model and importantly the particles cross the blood brain barrier and enter into the tumor.
Future Directions:
- Clinical validation
Strengths:
- Enables specific targeting of chemotherapeutic to the tumor site
- Chemotherapeutic has therapeutic efficacy as demonstrated by increased survival
Weaknesses:
- Prototype has not yet been fully validated (evaluation ongoing)
- Patent application is provisional and unpublished at this time
Patent Status:
Legal status: Pending
- Priority date: Pending
- Filing date: Pending
- Publication date: Pending
Publication PMID: 26284300, 26391797, 27490757
Publications:
Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF, Farrow N, Dobson J, Conner J, Wild JM, Lewis C. Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting. Nat Commun. 2015 Aug 18;6:8009.
Bain J, Ruiz-Pérez L, Kennerley AJ, Muench SP, Thompson R, Battaglia G, Staniland SS. In situ formation of magnetopolymersomes via electroporation for MRI. Sci Rep. 2015 Sep 22;5:14311.
Bakhshi PK, Bain J, Gul MO, Stride E, Edirisinghe M, Staniland SS. Manufacturing Man-Made Magnetosomes: High-Throughput In Situ Synthesis of Biomimetic Magnetite Loaded Nanovesicles. Macromol Biosci. 2016 Nov;16(11):1555-1561.
Inventor Bio: Munitta Muthana
https://www.sheffield.ac.uk/oncology-metabolism/staff/muthana
