Loupe-Based Intraoperative Fluorescence Imaging Device for the Guidance of Tumor Resection
Patent Number: WO2019014205A1
Executive Summary:
General Description:
This device is a novel, low-cost, wearable, loupe-based fluorescence imaging technique to enable neurosurgeons to easily identify tumor margins during surgery. This device is the first wearable fluorescence eye-loupe for brain tumor imaging.
Scientific Progress:
Tested in visualizing tissue for resection in a human patient.
Future Directions:
Strengths:
Weaknesses:
Patent Status:
Legal status: Pending
Publication PMID: 27564315
Publications:
Huang, C., Gu, Y., Chen, J., Bahrani, A. A., Abu Jawdeh, E. G., Bada, H. S., … Chen, L. (2019). A Wearable Fiberless Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Mice. IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 1–8. https://doi.org/10.1109/JSTQE.2018.2854597
Dong L, Kudrimoti M, Irwin D, Chen L, Kumar S, Shang Y, Huang C, Johnson EL, Stevens SD, Shelton BJ, Yu G. Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes. J Biomed Opt. 2016 Aug 1;21(8):85004.
Inventor Bio: Guoqiang Yu
http://www.uky.edu/~gyu2/UKBiomedicalOpticsLab/LabDirector.htm
Executive Summary:
- Invention Type: Device
- Patent Status: Pending
- Patent Link: https://patents.google.com/patent/WO2019014205A1/
- Research Institute: University of Kentucky
- Disease Focus: Brain tumors
- Basis of Invention: Customized loupe-based device with visualization aid to direct visible light and fluorescent dye exciting light at the surgical site
- How it works: The device contains a magnifying lens and visualization aid comprising a dual light source, beam splitter, and camera. The camera may be connected to a computer, and it is customizable
- Lead Challenge Inventor: Guoqiang Yu
- Inventors: Guoqiang Yu, Thomas Pittman, Chong Huang, Nick McGregor
- Development Stage: Prototype in testing
- Novelty:
- Wearable fluorescence eye-loupes for brain tumor imaging
- Clinical Applications:
- Adjustable magnification for neurosurgery
- Improved ability to distinguish glial tumors from normal tissue
General Description:
This device is a novel, low-cost, wearable, loupe-based fluorescence imaging technique to enable neurosurgeons to easily identify tumor margins during surgery. This device is the first wearable fluorescence eye-loupe for brain tumor imaging.
Scientific Progress:
Tested in visualizing tissue for resection in a human patient.
Future Directions:
- Additional optimization for easy and accurate use in a real-time surgical setting
Strengths:
- Easily adjustable and customizable for the surgeon
- Dual light source
- Ability to connect camera to computer
- Ability to visualize fluorescent dye at surgical site
Weaknesses:
- Many factors can affect performance and accuracy of the device
- Does not currently allow for changing from fluorescence view to color vision and vice versa
- Component parts are not optimal in terms of weight, size, quality, and ease of use
- Further calibration against established standards for imaging quality and accuracy is needed
Patent Status:
Legal status: Pending
- Priority date: 2017-07-10
- Filing date: 2018-07-10
- Publication date: 2019-01-17
Publication PMID: 27564315
Publications:
Huang, C., Gu, Y., Chen, J., Bahrani, A. A., Abu Jawdeh, E. G., Bada, H. S., … Chen, L. (2019). A Wearable Fiberless Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Mice. IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 1–8. https://doi.org/10.1109/JSTQE.2018.2854597
Dong L, Kudrimoti M, Irwin D, Chen L, Kumar S, Shang Y, Huang C, Johnson EL, Stevens SD, Shelton BJ, Yu G. Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes. J Biomed Opt. 2016 Aug 1;21(8):85004.
Inventor Bio: Guoqiang Yu
http://www.uky.edu/~gyu2/UKBiomedicalOpticsLab/LabDirector.htm
